by K.D. Miller
NOMINATED FOR THE 2019 SCOTIABANK GILLER PRIZE
SHORTLISTED FOR THE 2019 TRILLIUM BOOK AWARD
NOMINATED FOR THE TORONTO BOOK AWARD
AS HEARD ON CBC’S THE NEXT CHAPTER WITH SHELAGH ROGERS
A GLOBE AND MAIL BEST BOOK OF 2018
A QUILL & QUIRE BEST BOOK OF 2018
A 49TH SHELF EDITOR’S PICK
Inspired by the work of Alex Colville, the linked stories in K.D. Miller’s Late Breaking form a suite of portraits that evoke the paintings’ looming atmospheres and uncanny stillness while traveling deeply into their subjects’ vividly imagined lives. Throughout, the collection bears witness to the vulnerability of the elder heart, revealing that love, sex, and heartbreak are not only the domain of the young, and deftly rendering the conflicts that divide us and the ties that bind.
Husbands and wives struggle to communicate, romantic relationships flare and falter, parents and children navigate their complicated feelings, and older women struggle with diminishing status in a youth-obsessed culture while the threat of violence haunts young women and girls. Yet as the stories intersect and the characters’ lives are increasingly entwined, fear, guilt, estrangement, and the fact of death are met by courage, redemption and the fragile beauty of love, in all its myriad guises.
Brilliantly observed, both tender and tortured, and in no way afraid of the dark, these stories confirm K.D. Miller as one of our best and bravest writers.
Progressive Multiple Sclerosis
by Alastair Wilkins
Progressive multiple sclerosis places a huge burden on individuals, carers and society and treatment options are currently limited. However, there have been significant recent advances in understanding progressive disease and this book draws the field together into a single, accessible, clinically focused text.
Progressive Multiple Sclerosis sets out the basic science, pathology, epidemiology and treatment possibilities in progressive multiple sclerosis. The biological processes underlying disease progression are elucidated as are specific pathophysiological mechanisms. The basic science of axonal degeneration and the clinical understanding of progressive multiple sclerosis are discussed in the context of emerging and future therapies for disease progression as are trials which might be conducted for progressive multiple sclerosis. An overview of biomarkers for the disease is included and existing symptomatic therapies for progressive multiple sclerosis are covered in detail. Each chapter addresses specific aspects of progressive multiple sclerosis providing an extensive review of the current literature and a discussion of the likely mechanisms of tissue injury relevant to the disease.
Progressive Multiple Sclerosis is ideal for both general neurologists and those with a specialist interest in multiple sclerosis. It will also be of interest to neurologists in training and other medical professionals treating this common disease.
Dr Alastair Wilkins is Senior Lecturer in Neurology, University of Bristol, and Consultant Neurologist at Frenchay Hospital, Bristol, UK. He researches axonal injury in multiple sclerosis and related disorders.
by Alireza Minagar
Neuroinflammation, Second Edition, discusses the role inflammation plays in neuro-inflammatory diseases. As research in neuroinflammation has dramatically increased in recent years, this new edition covers all of the new developments and findings since the first publication nearly a decade ago. Comprehensive coverage of topics includes chapters on multiple sclerosis, optic neuritis and Susac syndrome. New chapters cover the latest research in Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury, amongst other topics.
Inflammation is a central mechanism in many neurological diseases, including stroke, multiple sclerosis, brain trauma and meningitis, and it contributes to the generation of pain. Researchers are now beginning to understand the impact of the immune system on different nervous system functions and diseases, ranging from damage, through tolerance, and to modulation and repair.
- Comprehensively reviews the latest developments in neuroinflammation and neuro-inflammatory diseases
- Written for researchers and clinical practitioners in clinical neuroscience, neurology and immunology
- Includes new chapters on Epilepsy and Neuroinflammation, Pediatric MS, Pediatric Lupus and Traumatic Brain Injury
Multiple Sclerosis for the Non-Neurologist
by Mary Ann Picone
by Rosemary Forrest, Nicole Baugh
Extraskeletal Effects of Vitamin D
by Emilia Pauline Liao
This book provides an in-depth examination of these extraskeletal effects of vitamin D and the associations between vitamin D deficiency and various disease states. Beginning with a review of the biochemistry and physiology of vitamin D, subsequent chapters investigate its relationship to autoimmune and infectious diseases, various forms of cancer, endocrine issues such as diabetes, obesity and reproductive function, cardiovascular disease and muscle weakness. Concluding chapters discuss the role of vitamin D in neurological disorders, including Alzheimer’s Disease, and cognitive function.
Focusing on extraskeletal effects only across a range of conditions, Extraskeletal Effects of Vitamin D will be an important resource for clinical endocrinologists and primary care physicians.
Understanding Multiple Sclerosis
by Melissa Stauffer
Two-and-a-half million people world-wide and 400,000 Americans suffer from the chronic disease multiple sclerosis. Understanding Multiple Sclerosis presents both general information about MS and valuable, specific advice.
Who gets MS? What are its symptoms? What are its effects on the bodies and minds of people afflicted? How does one plan for the future after a diagnosis? From basic biology to new advances in treatment, Understanding Multiple Sclerosis covers the topics most relevant to people with MS and to their families and friends.
- Introduction to genetic, demographic, and geographic factors
- Basic biology of MS, with descriptions of both the central nervous system and the immune system
- Characteristic symptoms of MS
- Diagnostic criteria and different types of MS
- Treatments, over-the-counter medica-tions, and alternative medicines
- Lifestyle adjustments and coping strate-gies along with advice on long-term health insurance and financial planning
- Current and ongoing MS research and advances
Melissa Stauffer of Daphne, Alabama, is a freelance science editor whose work has appeared in Biochemistry, Journal of Biological Chemistry, Journal of Biomolecular NMR, and FEBS Letters.
Regression Methods in Biostatistics
by Eric Vittinghoff, David V. Glidden, Stephen C. Shiboski, Charles E. McCulloch
This new book provides a unified, in-depth, readable introduction to the multipredictor regression methods most widely used in biostatistics: linear models for continuous outcomes, logistic models for binary outcomes, the Cox model for right-censored survival times, repeated-measures models for longitudinal and hierarchical outcomes, and generalized linear models for counts and other outcomes.
Treating these topics together takes advantage of all they have in common. The authors point out the many-shared elements in the methods they present for selecting, estimating, checking, and interpreting each of these models. They also show that these regression methods deal with confounding, mediation, and interaction of causal effects in essentially the same way.
The examples, analyzed using Stata, are drawn from the biomedical context but generalize to other areas of application. While a first course in statistics is assumed, a chapter reviewing basic statistical methods is included. Some advanced topics are covered but the presentation remains intuitive. A brief introduction to regression analysis of complex surveys and notes for further reading are provided. For many students and researchers learning to use these methods, this one book may be all they need to conduct and interpret multipredictor regression analyses.
The authors are on the faculty in the Division of Biostatistics, Department of Epidemiology and Biostatistics, University of California, San Francisco, and are authors or co-authors of more than 200 methodological as well as applied papers in the biological and biomedical sciences. The senior author, Charles E. McCulloch, is head of the Division and author of Generalized Linear Mixed Models (2003), Generalized, Linear, and Mixed Models (2000), and Variance Components (1992).
From the reviews:
“This book provides a unified introduction to the regression methods listed in the title…The methods are well illustrated by data drawn from medical studies…A real strength of this book is the careful discussion of issues common to all of the multipredictor methods covered.” Journal of Biopharmaceutical Statistics, 2005
“This book is not just for biostatisticians. It is, in fact, a very good, and relatively nonmathematical, overview of multipredictor regression models. Although the examples are biologically oriented, they are generally easy to understand and follow…I heartily recommend the book” Technometrics, February 2006
“Overall, the text provides an overview of regression methods that is particularly strong in its breadth of coverage and emphasis on insight in place of mathematical detail. As intended, this well-unified approach should appeal to students who learn conceptually and verbally.” Journal of the American Statistical Association, March 2006
Biomarkers of Neuroinflammation
by National Academies of Sciences, Engineering, and Medicine, Health and Medicine Division, Board on Health Sciences Policy, Forum on Neuroscience and Nervous System Disorders
Neuroinflammation is a burgeoning area of interest in academia and biopharma, with a broadly acknowledged role in many central nervous system (CNS) disorders. However, there is little agreement on the pathophysiological mechanisms that underlie the manifestations of neuroinflammation in the CNS compartment and how neuroinflammation operates as a driver and also as a consequence of disease in the brain. Moreover, another unclear area is how to translate increased understanding of the mechanisms that underlie neuroinflammation and its manifestations in the CNS to therapeutics.
To address these gaps in understanding mechanisms and how to translate that understanding into therapeutics, the Forum on Neuroscience and Nervous System Disorders of the National Academies of Sciences, Engineering, and Medicine convened a workshop on March 20-21, 2017, bringing together key leaders in the field from industry, academia, and governmental agencies to explore the role and mechanisms of neuroinflammation in a variety of CNS diseases. The workshop also considered strategies to advance the identification and validation of biomarkers of neuroinflammation that could accelerate development of therapies, bringing much-needed treatments to patients with disorders ranging from neuroinflammatory diseases such as multiple sclerosis (MS) to neuropsychiatric disorders such as depression. This publication summarizes the presentations and discussions from the workshop.